Incorporating children's toxicokinetics into a risk framework.

A framework for assessing risks to children from exposure to environmental agents.

In recent years there has been an increasing focus in environmental risk assessment on children as a potentially susceptible population. There also has been growing recognition of the need for a systematic approach for organizing, evaluating, and incorporating the available data on children's susceptibilities in risk assessments. In this article we present a conceptual framework for assessing r...

A Toxicological Framework for the Prioritization of Children's Safe Product Act Data.

In response to concerns over hazardous chemicals in children's products, Washington State passed the Children's Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children's products. We describe a framework for the toxicological prioritization of the ten chemical groups most frequently reported under CSPA. The framework scores lifestage, exposur...

Measuring and incorporating attitudes toward risk into mathematical programming models : the case of farmers in kavar district iran

Exposure and Effects Assessment Essentiality Effects Assessment Forms of metals Exposure and Effects Assessment Toxicokinetics/toxicodynamics Exposure Assessment (bioavailability) and Effects Assessment (ADME and toxicity) 6.2. CHARACTERIZATION OF EXPOSURE Metal exposure assessment includes characterization of the exposure routes and pathways

This section of the Framework provides an overview of how the principles for metals risk assessment apply to ecological risk assessments for terrestrial environments. Receptors typically considered in these assessments include soil invertebrates, plants, and wildlife species. Some assessments also examine effects on microbiota and soil processes. This section of the Framework builds on the info...

Toxicokinetics/toxicodynamics with damage feedback improves risk assessment for tilapia and freshwater clam exposed to arsenic.

It has been proposed that irreversible responses of organisms exposed to contaminants are due to a systems-level feedback. Here we tested this hypothesis by reanalyzing the published data on toxicokinetics and survival probability based on a systems-level threshold damage model (TDM) incorporating with a positive damage feedback to explore the steady-state response and dynamic behavior of damag...